Nance attended the University of North Carolina - Chapel Hill graduating in 1992 with a degree of BS Pharmacy. She attended Wake Forest University School of Medicine and graduated in 1996. She completed her residency at Memorial Hermann Southwest in Houston, TX as chief-resident. She has been employed with Piedmont Healthcare in Statesville, NC, since 1999 and served as Medical Director for both Piedmont Healthcare and the newly formed Piedmont Community Health Collaborative ACO since June 2016. She opened her own practice, Nance Family Medicine in 2005.